Summary: Few therapies target the loss of tumor suppressor genes in cancer.We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new therapeutic targets associated with genomic loss of tumor suppressor genes.The endosomal sorting complexes required for transport (ESCRT) ATPases VPS4A and VPS4B score as strong synthetic
Introduction: Sloths are arboreal mammals that defecate on the ground, increasing the risk of predation.There are several Bladder Health hypotheses that try to explain why they undergo this risk.Objective: To critically review all the hypotheses and to propose a new hypothesis that is compatible with all known data.Methods: I verified the assumptio
We present a general formalism for giving a measure space paired with a separable Hilbert space a quantum version based on a normalized positive operator-valued measure.The latter are built from families of density ORG KIDNEY BEANS operators labeled by points of the measure space.We especially focus on various probabilistic aspects of these constru
ABSTRACT Larvae of stomatopods (mantis shrimps) are generally categorized into four larval types: antizoea, pseudozoea (both representing early larval stages), alima and erichthus (the latter two representing later larval stages).These categories, however, do not Mirrors reflect the existing morphological diversity of stomatopod larvae, which is la
Wild birds are the reservoir for low-pathogenic avian influenza viruses, which are frequently transmitted to domestic birds and occasionally to mammals.In 2014, an H10N7 virus caused severe mortality in harbor seals in northeastern Europe.Although the hemagglutinin (HA) of this virus was closely related to H10 of avian H10N4 virus, it possessed uni